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. 2015 Jun 15;3(6):e12427. doi: 10.14814/phy2.12427

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© 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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The correlation between coronary vascular resistance and end-diastolic tension in isolated hearts of WT (n = 12) and sEH-KO (n = 9) mice. (A) Correlation coefficient is −0.7316 (P < 0.0001) and −0.7702 (P < 0.0001) in WT and sEH-KO hearts, respectively. The slope of regression line is -3.329 ± 0.2358 (WT) and −4.582 ± 0.271 (sEH-KO). The difference between the two slopes is statistically significant (P < 0.001). (B) Changes in end-diastolic tension and coronary resistance were normalized by heart weights. Correlation coefficient is −0.7348 (P < 0.0001) and −0.7715 (P < 0.0001) in WT and sEH-KO hearts, respectively. The slope of regression line is −3.322 ± 0.2346 (WT) and −4.593 ± 0.2722 (sEH-KO). The difference between the two slopes is statistically significant (P < 0.0001).