Table 1. Genotype and allele frequencies of TNF-α and TNF-β variants in oral lichen planus patients and matched controls.
| Genotype/ allele | OLP (N=42) | Control (N=200) | |||||
|---|---|---|---|---|---|---|---|
| N | % | N | % | P-value | RR | EF†/ PF | |
| -308 G/A | |||||||
| GG | 5 | 11.9 | 110 | 55 | <0.001* | 0.11 | 0.257 |
| GA | 36 | 85.72 | 76 | 38 | <0.001* | 9.789 | 0.288† |
| AA | 1 | 2.38 | 14 | 7 | 0.479 | 0.324 | 0.121 |
| G allele | 46 | 54.76 | 296 | 74 | <0.001* | 0.425 | 0.153 |
| A allele | 38 | 45.24 | 104 | 26 | <0.001* | 2.351 | 0.153† |
| +252 A/G | |||||||
| GG | 4 | 9.52 | 28 | 14 | 0.616 | 0.647 | 0.063 |
| GA | 38 | 90.48 | 148 | 74 | 0.025* | 6.767 | 0.173† |
| AA | 0 | 0 | 24 | 12 | 0.010* | - | - |
| G allele | 46 | 54.76 | 204 | 51 | 0.55 | 1.163 | 0.026† |
| A allele | 38 | 45.24 | 196 | 49 | 0.55 | 0.859 | 0.026 |
N=number of subjects,*statistically significant, RR=relative risk, EF=etiologic fraction, PF=preventive fraction