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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Cancer Immunol Res. 2014 Nov 11;3(4):320–325. doi: 10.1158/2326-6066.CIR-14-0100

Figure 1. Detection of Anti-GMCSF polyclonal antibodies.

Figure 1

A) Polyclonal antibody fluorescence index (MFI) against GM-CSF is plotted over time coinciding with vaccine and apheresis administrations. Anti-GM-CSF antibodies (IgG+ IgM) increases over time with repeated vaccinations using recombinant GM-CSF and begin to decrease after the adjuvant is removed.

B) Polyclonal antibody fluorescence index (MFI) against GM-CSF is graphed at vaccine #8 with and without competitive blockade of the polyclonal antibody. Competitive antibody blockade decreases the detection of anti-GM-CSF antibodies as measured by MFI at vaccine #8.