Table 2. SNPs Significantly Associated with SCD and All Cause Death.
| SNP/ Ending Point | Model | Cox Regression | |
|---|---|---|---|
| P Value/HR(95%CI) | Adjusted P Value/HR(95%CI) | ||
| rs361508/SCD | DOM | 0.050/1.379(1.001 1.900) | 0.033†/1.576(1.037 2.396) |
| REC | 0.121/1.313(.931 1.852) | 0.098/1.444(.935 2.230) | |
| ADDITIVE | 0.030†/1.247(1.021 1.524) | 0.002‡/1.329(1.026 1.721) | |
| rs361508/NSCD | DOM | 0.921/1.011(.812 1.259) | 0.719/1.049(.809 1.360) |
| REC | 0.18/1.192(.922 1.540) | 0.401/1.144(.835 1.567) | |
| ADDITIVE | 0.426/1.061(.917 1.228) | 0.486/1.064(.893 1.268) | |
| rs361508/ACD | DOM | 0.217/1.120(.935 1.342) | 0.136/1.182(.949 1.474) |
| REC | 0.046†/1.233(1.004 1.514) | 0.107/1.233(.956 1.590) | |
| ADDITIVE | 0.055/1.122(.997 1.263) | 0.059/1.149(.995 1.327) | |
| rs3814843/SCD | DOM | 0.245/1.247(.859 1.809) | 0.24/1.318(.831 2.090) |
| REC | 0.001‡/5.542(2.054 14.948) | 0.001‡/7.466(2.604 21.403) | |
| ADDITIVE | 0.001‡/2.372(1.442 3.900) | 0.001‡/2.717(1.598 4.619) | |
| rs3814843/NSCD | DOM | 0.789/.961(.716 1.289) | 0.853/.968(.686 1.366) |
| REC | 0.145/2.331(.747 7.269) | 0.068/2.957(.924 9.461) | |
| ADDITIVE | 0.988/.998(.754 1.320) | 0.882/1.025(.741 1.418) | |
| rs3814843/ACD | DOM | 0.641/1.056(.839 1.330) | 0.621/1.072(.814 1.412) |
| REC | 0.001‡/3.484(1.651 7.350) | 0.001‡/4.501(2.078 9.749) | |
| ADDITIVE | 0.001‡/1.866(1.284 2.712) | 0.001‡/2.050(1.389 3.023) | |
| rs1800051/SCD | DOM | 0.028†/1.391(1.036 1.867) | 0.021†/1.553(1.068 2.259) |
| REC | 0.111/1.642(.893 3.020) | 0.471/1.397 (.563 3.465) | |
| ADDITIVE | 0.015†/1.342(1.058 1.702) | 0.026†/1.422(1.043 1.937) | |
| rs1800051/NSCD | DOM | 0.337/1.113(.894 1.386) | 0.182/1.193(.920 1.547) |
| REC | 0.085/.518(.245 1.094) | 0.557/.783(.346 1.771) | |
| ADDITIVE | 0.825/1.021(.847 1.232) | 0.330/1.118(.893 1.399) | |
| rs1800051/ACD | DOM | 0.039†/1.204(1.010 1.434) | 0.016†/1.299(1.050 1.608) |
| REC | 0.628/.890(.556 1.424) | 0.936/.975(.532 1.788) | |
| ADDITIVE | 0.109/1.128(.973 1.306) | 0.039†/1.211(1.010 1.452) | |
SNP, single nucleotide polymorphism; DOM, dominant genetic model; REC, recessive genetic model; ADDITIVE, additive genetic model; SCD, sudden cardiac death; NSCD, non- sudden cardiac death; ACD, all cause death. Model 1: unadjusted model. Model 2: model 1+age, LVEF, and other factors, including New York Heart Association Functional class, hypertension, diabetes mellitus, etc.
†P<0.05, possibly significant associated.
‡P<0.0025, significant associated. Since we have 20 SNPs, we choose the significant cut-off point at 0.05/20 = 0.0025 level.