Table I.
Classification of voltage-gated calcium channels (VGCCs).
Classification of voltage-gated calcium channels (Cav) according to alphabetical nomenclature, electrophysiological properties (HVA: high voltage activated, LVA: low voltage activated), genetic determinants and dihydropyridine (DPH) sensitivity.
| Type | Voltage | α1 subunit (gene) Chromosome | DPH sensitivity |
|---|---|---|---|
| L-type calcium channel | HVA | Cav1.1 (CACNA1S) 1q32 Cav1.2 (CACNA1C) 12p13.3 Cav1.3 (CACNA1D) 3p14.3 Cav1.4 (CACNA1F) Xp11.23 |
Blocked |
| P/Q-type calcium channels | HVA | Cav2.1 (CACNA1A) 19p13 | Resistant |
| N-type calcium channel | HVA | Cav2.2 (CACNA1B) 9q34 | Resistant |
| R-type calcium channel | Intermediate | Cav2.3 (CACNA1E) 1q25.3 | Resistant |
| T-type calcium channel | LVA | Cav3.1 (CACNA1G) 17q22 Cav3.2 (CACNA1H) 16p13.3 Cav3.3 (CACNA1L) 22q13.1 |
Partially blocked |