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. Author manuscript; available in PMC: 2015 Jul 22.
Published in final edited form as: Compr Physiol. 2015 Jul 1;5(3):1265–1280. doi: 10.1002/cphy.c140074

Figure 5.

Figure 5

Selected examples of pro-inflammatory effects of platelets resulting in functional consequences on leukocytes. Platelets interact with leukocytes through both adhesive mechanisms as well as release of cytokines/chemokines. This results in leukocyte activation and enhanced leukocyte-endothelial adhesion. Through these mechanisms, platelets participate in several normal and pathologic immune functions including microbial killing, leukocyte homing, wound healing, allergic inflammation, and atherosclerosis, among others.