. Author manuscript; available in PMC: 2015 Jul 22.

Published in final edited form as: Compr Physiol. 2015 Jul 1;5(3):1265–1280. doi: 10.1002/cphy.c140074

Table 1.

Selected examples of soluble element-mediated interactions between platelets and leukocytes

Platelet Element	Leukocyte Element	Effect (References)
sCD40L	CD40	Atherosclerosis (28) Inflammatory bowel disease (206)
Platelet factor 4	Chondroitin sulfate (neutrophils)	Activation of neutrophils (159)
Platelet factor 4	CXCR3B (microvascular endothelial cells)	Regulating angiogenesis (121, 203)
Fibrinogen	Mac-1 (neutrophils)	Neutrophil adhesion to fibrin deposits (114, 232)
TLR4	Histones (neutrophils)	Platelet activation and thrombosis (68, 117, 223)
?	DNA (neutrophils)	Thrombosis (50, 69)
RANTES (CCL5)	CCR5 (monocytes, endothelium)	Monocyte arrest on HMVEC (9) Development of atherosclerosis (77)
RANTES (CCL5)	CCR5 (endothelium, leukocytes)	Cerebral microvascular dysfunction and inflammation in I/R (199)
LIGHT (TNFSF14)	Herpes virus entry mediator (HVEM; neutrophils, monocytes)	Enhances phagocytosis and bactericidal activity (84)
LIGHT (TNFSF14)	HVEM (endothelial cells) Lymphotoxin beta receptor (LTβR; endothelial cells)	Platelet-endothelial interactions; Levels elevated in STEMI (33)
?	Myeloperoxidase (MPO; neutrophils) Hydrogen peroxide (H₂O₂)	MPO and H₂O₂ induce platelet secretion of serotonin and adenine (39)
LPS-stimulated platelet	??? (neutrophils)	Release of neutrophil extracellular traps (40)
Platelet activating factor	CR1 (monocytes)	Enhances phagocytosis (31)