Table 1.
List of all genes where Smad2/3 binding is maintained at the same position in control and E2a-depleted embryos, and that are significantly downregulated in E2a-depleted embryos. For each gene, the normalized mean expression level is shown (mean expression in E2a-depleted embryos divided by mean expression in control embryos). Gene categories are assigned as: transcription factor; cytoskeleton/transport; transmembrane receptor; signaling molecule; intracellular signaling (including secondary messenger proteins) and other/unknown (including all other major functions).
| Gene name | Expression (mean E2a-/mean Ctrl) | Function type |
|---|---|---|
| mespb | 0.008080432 | Transcription factor |
| cer1 | 0.010092776 | Signaling molecule |
| pcdh8.2 | 0.010779418 | Cytoskeleton/transport |
| t (xbra) | 0.027910383 | Transcription factor |
| frzb | 0.033973786 | Transmembrane receptor |
| gatm | 0.058238471 | Other/Unknown |
| lhx1 | 0.061176421 | Transcription factor |
| hhex | 0.075792824 | Transcription factor |
| gs17 | 0.082842955 | Other/unknown |
| foxa4 | 0.105938633 | Transcription factor |
| gsc | 0.111275047 | Transcription factor |
| gata4 | 0.112514562 | Transcription factor |
| slc38a3 | 0.135985709 | Cytoskeleton/transport |
| rspo2 | 0.155234594 | Signaling Molecule |
| nudt22 | 0.173302279 | Other/Unknown |
| foxc2 | 0.183713832 | Transcription factor |
| foxd3 | 0.195581307 | Transcription factor |
| epha4 | 0.244381447 | Transmembrane receptor |
| otx2 | 0.265712657 | Transcription factor |
| gata5 | 0.279417037 | Transcription factor |
| ngfr | 0.28420678 | Transmembrane receptor |
| ror2 | 0.298173092 | Signaling molecule |
| nr6a1 | 0.305514516 | Transcription factor |
| eomes | 0.327671011 | Transcription factor |
| cox7b | 0.381125295 | Other/Unknown |
| wnt5b | 0.389808629 | Signaling molecule |
| zic3 | 0.436294732 | Transcription factor |
| hpdl | 0.439688059 | Other/Unknown |
| efna1 | 0.459150746 | Signaling molecule |
| ventx1.1 | 0.487513979 | Transcription factor |
| snai1 | 0.506217054 | Transcription factor |
| vegt | 0.514365172 | Transcription factor |
| fgf8 | 0.53150366 | Signaling molecule |
| pkdcc.1 | 0.534870368 | Other/Unknown |
| gata6 | 0.54800291 | Transcription factor |
| tsg101 | 0.550753067 | Cytoskeleton/transport |
| crx | 0.564716113 | Transcription factor |
| map2k6 | 0.586210367 | Intracellular signaling |
| wnt11 | 0.590079259 | Signaling molecule |
| MGC76328 | 0.593841587 | Other/unknown |
| znf703 | 0.597459616 | Transcription factor |
| cdc42ep4 | 0.642916664 | Cytoskeleton/transport |
| lpar2 | 0.644983354 | Transmembrane receptor |
| stx6 | 0.64601592 | Cytoskeleton/Transport |
| LOC496805 | 0.671603875 | Unknown/Other |
| fzd8 | 0.695453455 | Transmembrane receptor |