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. 2015 Jul 22;6:147. doi: 10.3389/fphar.2015.00147

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Copyright © 2015 Abu-Sanad, Wang, Hasheminasab, Panasci, Noë, Rosca, Davidson, Amrein, Sharif-Askari, Aloyz and Panasci.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of combination drug treatments (24 h) on the expression and phosphorylation status of DNA-PK (S2056) in 3 colon cancer cell lines as determined by western blot analysis, representative of 3 replicates. (A) HCT-116 cells treated with: NT = vehicle treated control, S8 = 8 nM SN38, S32 = 32 nM SN38, S64 = 64 nM SN38, A0.5 = .5 μM ABT-888, V1 = 1 μM VE-821, and V2 = 2 μM VE-821. (B) HT-29 (black bars) and LoVo (white bars) cells treated with S64 = 64 nM SN38, A0.5 = 0.5 μM ABT-888, V1 = 1 μM VE-821 alone or in combinations as indicated. ^*Significantly different from NT cells, ^εsignificantly different from S64 cells, ^θsignificantly different from cells treated with SN38 and corresponding levels of VE-821, p ≤ 0.05.