Table 2.
Proportion of decreased MMR protein expression in Lynch syndrome adenomas and carcinomas
| Proportion (%) with decreased MMR protein corresponding to the gene mutated in germline | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MLH1 | p value vs. normal colon | p value vs. low dysplasia | MSH2 | p value vs. normal colon | p value vs. low dysplasia | MSH6 | p value vs. normal colon | p value vs. low dysplasia | Total | p value vs. normal colon | p value vs. low dysplasia | |
| Normal colon | 0/33 (0 %) | 0/7 (0 %) | 0/3 (0 %) | 0/43 (0 %) | ||||||||
| Adenoma low dysplasia | 17/25 (68 %) | <0.0001 | 4/6 (67 %) | 0.021 | 1/2 (50 %) | NS | 22/33 (67 %) | <0.0001 | ||||
| Adenoma high dysplasia | 13/13 (100 %) | <0.0001 | 0.034 | 1/1 (100 %) | NS | NS | – | NS | 14/14 (100 %) | <0.0001 | 0.020 | |
| Carcinoma | 12/12 (100 %) | <0.0001 | 0.036 | 3/3 (100 %) | 0.008 | NS | 5/5 (100 %) | 0.018 | NS | 20/20 (100 %) | <0.0001 | 0.003 |
NS, no statistical significance