Table 2.

Univariate analysis of OS and RFS: expression of each gene was categorized as low or high at the 66.7th percentile

Marker	Group	Status	Number of patients	OS			RFS
				5-Year survival (%)	HR (95 % CI)	P value (log-rank)	5-Year survival (%)	HR (95 % CI)	P value (log-rank)
TS	All	Low	540	66.5	1	0.222	58.1	1	0.085
		High	268	71.8	0.844 (0.642–1.109)		66.2	0.805 (0.629–1.031)
	S-1	Low	275	69.9	1	0.008	62.2	1	0.003
		High	127	83.9	0.521 (0.319–0.850)		78.9	0.530 (0.344–0.816)
	Surgery only	Low	265	63.0	1	0.623	53.8	1	0.923
		High	141	60.8	1.088 (0.777–1.522)		54.9	1.015 (0.747–1.380)
DPD	All	Low	539	68.9	1	0.589	60.8	1	0.941
		High	268	66.9	1.075 (0.828–1.395)		60.6	1.009 (0.796–1.279)
	S-1	Low	271	73.2	1	0.522	66.0	1	0.444
		High	130	76.3	0.870 (0.568–1.333)		70.1	0.862 (0.590–1.261)
	Surgery only	Low	268	64.5	1	0.230	55.5	1	0.486
		High	138	58.0	1.225 (0.879–1.708)		51.6	1.114 (0.822–1.509)
TP	All	Low	539	66.7	1	0.233	59.2	1	0.209
		High	268	71.1	0.848 (0.647–1.112)		63.8	0.856 (0.672–1.091)
	S-1	Low	260	72.3	1	0.317	65.8	1	0.368
		High	141	77.6	0.806 (0.528–1.230)		70.2	0.843 (0.581–1.223)
	Surgery only	Low	279	61.5	1	0.585	53.1	1	0.512
		High	127	63.8	0.907 (0.637–1.290)		56.6	0.898 (0.652–1.238)
OPRT	All	Low	540	66.2	1	0.120	58.4	1	0.108
		High	267	72.2	0.805 (0.612–1.059)		65.7	0.818 (0.639–1.046)
	S-1	Low	260	71.6	1	0.125	64.9	1	0.196
		High	141	78.9	0.715 (0.465–1.100)		72.0	0.779 (0.533–1.139)
	Surgery only	Low	280	61.2	1	0.635	52.3	1	0.436
		High	126	64.7	0.918 (0.644–1.309)		58.7	0.879 (0.636–1.216)