Table 3.

Univariate analysis of OS and RFS: expression of each gene was categorized as low or high at the 33.3rd percentile

Marker	Group	Status	Number of patients	OS			RFS
				5 year survival (%)	HR (95 % CI)	P value (log-rank)	5 year survival (%)	HR (95 % CI)	P value (log-rank)
TS	All	Low	272	67.9	1	0.969	57.1	1	0.292
		High	536	68.4	0.995 (0.766–1.293)		62.7	0.883 (0.700–1.113)
	S-1	Low	138	72.3	1	0.595	62.9	1	0.270
		High	264	75.3	0.897 (0.599–1.341)		70.0	0.819 (0.574–1.169)
	Surgery only	Low	134	63.2	1	0.769	51.1	1	0.559
		High	272	61.8	1.053 (0.745–1.488)		55.7	0.913 (0.672–1.240)
DPD	All	Low	269	64.7	1	0.137	57.9	1	0.180
		High	538	69.9	0.823 (0.636–1.064)		62.2	0.853 (0.676–1.076)
	S-1	Low	136	66.8	1	0.015	60.8	1	0.039
		High	265	78.0	0.616 (0.416–0.914)		70.8	0.690 (0.485–0.983)
	Surgery only	Low	133	62.6	1	0.942	55.1	1	0.978
		High	273	62.1	1.013 (0.718–1.429)		53.8	0.996 (0.730–1.359)
TP	All	Low	269	64.4	1	0.148	56.8	1	0.168
		High	538	70.0	0.827 (0.640–1.070)		62.7	0.850 (0.673–1.072)
	S-1	Low	129	67.7	1	0.067	62.0	1	0.116
		High	272	77.2	0.690 (0.463–1.029)		69.8	0.750 (0.523–1.075)
	Surgery only	Low	140	61.5	1	0.831	52.0	1	0.776
		High	266	62.6	0.964 (0.688–1.351)		55.3	0.957 (0.706–1.296)
OPRT	All	Low	269	67.1	1	0.838	57.0	1	0.246
		High	538	68.7	0.973 (0.749–1.264)		62.6	0.872 (0.691–1.099)
	S-1	Low	129	74.3	1	0.907	66.4	1	0.877
		High	272	74.1	1.025 (0.674–1.559)		67.8	0.971 (0.671–1.406)
	Surgery only	Low	140	60.5	1	0.807	48.4	1	0.191
		High	266	63.2	0.959 (0.685–1.342)		57.3	0.819 (0.608–1.105)