Table 1.
Baseline characteristics of 200 patients with early diffuse systemic sclerosis*
| Baseline characteristic | No. | Value | IQR |
|---|---|---|---|
| Demographics | |||
| Age, years | 200 | 50.0 ± 11.9 | 42.9–37.6 |
| BMI, kg/m2 | 177 | 25.5 ± 5.5 | 21.6–28.5 |
| Disease duration, years | 193 | 1.6 ± 1.4 | 0.5–2.7 |
| Women, % | 150 | 75 | NA |
| Race, % | |||
| White | 157 | 79 | NA |
| African American | 18 | 9 | NA |
| Asian | 16 | 8 | NA |
| Other | 9 | 4 | NA |
| Hispanic | 19 | 10 | NA |
| Physician global assessment | 175 | 4.3 ± 2.2 | 3.0–6.0 |
| Patient global assessment | 177 | 3.9 ± 2.7 | 2.0–6.0 |
| SF-36 PCS | 174 | 37.9 ± 12.8 | 28.3–46.4 |
| SF-36 MCS | 174 | 44.2 ± 6.1 | 39.9–48.9 |
| Skin involvement | |||
| Physician reported | |||
| In the last month (0–10) | 183 | 4.0 ± 2.9 | 1.5–6.0 |
| In the last year (0–10) | 178 | 4.7 ± 3.0 | 2.0–7.0 |
| Skin severity (1–5) | 200 | 4.1 ± 1.5 | 3.0–5.0 |
| Patient reported | |||
| Skin condition interference with daily activities in last month (0–10) | 157 | 3.9 ± 3.2 | 1.0–7.0 |
| Skin condition interference with daily activities in last year (0–10) | 157 | 4.0 ± 3.2 | 1.0–7.0 |
| Skin involvement in the last month (0–10) | 171 | 3.3 ± 3.2 | 0.0–5.0 |
| Skin involvement in the last year (0–10) | 172 | 4.6 ± 3.3 | 2.0–7.3 |
| Physical examination | |||
| Modified Rodnan skin score | 200 | 20.6 ± 10.1 | 13.0–28.0 |
| Durometer, DU | 135 | 266.3 ± 66.6 | 219.2–307.9 |
| Skin progression rate | 193 | 63.8 ± 184.7 | 7.1–48.9 |
| Musculoskeletal | |||
| Patient reported | |||
| HAQ DI | 200 | 1.0 ± 0.8 | 0.1–1.5 |
| Laboratory/serology | |||
| Serum creatine phosphokinase, IU/liter | 161 | 167.1 ± 403.6 | 49.0–160.0 |
| ANA positive | 151 | 83 | – |
| Anticentromere positive | 103 | 12 | – |
| Anti-Scl 70 positive | 148 | 29 | – |
| Physical examination | |||
| Tendon friction rubs, % | 189 | 24 | NA |
| Small joint contractures, % | 182 | 52 | NA |
| Large joint contractures, % | 182 | 26 | NA |
| Tender joint count | 198 | 1.3 ± 2.7 | 0.0–1.8 |
*
Values are the mean ± SD unless indicated otherwise. IQR = interquartile range; BMI = body mass index; NA = not applicable; SF-36 = Short Form 36 health survey; PCS = physical component score; MCS = mental component score; DU = durometer units; HAQ = Health Assessment Questionnaire; DI = disability index; ANA = antinuclear antibody.