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. 2015 Apr 27;29(8):3436–3445. doi: 10.1096/fj.15-271171

Figure 5.

Figure 5.

rmWnt3a rescue of hepatic inflammation. A) Immunofluorescence analysis reveals hepatic CD68 expression before and after rmWnt3a treatment. B) Reduced expression of PNPLA3 in LRP6mut/mut and WT hepatocytes after rmWnt3a treatment is shown. C and D) Intraperitoneal administration of Wnt3a reduces activation of ROCK2 and RhoA. E) Western blot analysis demonstrates reduced expressions of MPO, F4/80, and IL-6 in LRP6mut/mut mouse liver after rmWnt3a administration. The relative intensities by densitometry are shown. Error bars represent sd. *P < 0.05; **P < 0.01.