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Reduction of hepatic fibrosis with Wnt3a activation. Liver fibrosis in Lrp6mut/mut mice was reduced after rmWnt3a administration, assayed by trichrome staining (A) and by immunofluorescence staining of α-SMA (B) and vimentin (C). D) Protein expression of the hepatic fibrosis inducer TGF-β1 was significantly rescued by rmWnt3a. The relative intensities by densitometry are shown. Error bars represent sd. *P < 0.05; **P < 0.01.
