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. 2015 Apr 24;29(8):3133–3140. doi: 10.1096/fj.14-266064

Figure 4.

Figure 4.

RBP4-KO does not protect from HFD-induced obesity or hypertension. Effect of chow vs. HFD on weight gain (A), BP (B), and ambient (C) and insulin-induced (D) aortic eNOSSer1177 phosphorylation in 18-wk-old WT and RBP4-KO mice. The mice were killed after withholding food overnight (C) or 15 minutes after intraperitoneal injection of saline or 6 mIU/g insulin in the unfed state (D). Bovine aortic endothelial cell (BAEC) lysates were run on the same gel as positive controls for eNOS. Twelve wk on an HFD [(A–C); n = 9–10/group; (D) n = 4–6/group]. *P < 0.05 vs. other genotypes, same diet; †P < 0.05 vs. same genotype, chow diet; ‡P < 0.05 vs. same genotype, saline injection.