Figure 5.

Differential response to recombinant IL-6 in fibroblasts derived from young and old MSCs. Quiescent fibroblasts were treated with one dose of recombinant IL-6 (50 ng/ml) and then cells were harvested 24 and 48 h later. A) Response of fibroblast derived from the young MSCs. B) Responses from fibroblasts derived from the old MSCs. P < 0.05 denotes statistical significance; the number in each column corresponds to the number of donor animals from which cells were derived for these experiments. Young signifies cells derived from 3-mo-old mice, and old denotes cells derived from 30-mo-old mice.