TABLE 3.
Genes of axonal guidance differentially expressed with age in ING at both ambient temperatures
| Gene symbol | Gene name | Fold change (10D/21D) | P (corr) | Raw signal 10D | Raw signal 21D |
|---|---|---|---|---|---|
| Ablim3 | Actin binding LIM protein family, member 3 | 2.19 | 9.65 E-7 | 12851.34 | 5096.22 |
| Akap12 | A kinase (PRKA) anchor protein 12 | 2.55 | 3.63E-6 | 23995.28 | 7418.80 |
| Bmp1 | Bone morphogenetic protein 1 | 2.07 | 3.15E-4 | 3347.90 | 1376.44 |
| Bmp3 | Bone morphogenetic protein 3 | 4.69 | 5.47E-7 | 1556.17 | 277.67 |
| Cxcr4 | Chemokine (C-X-C motif) receptor 4 | −2.56 | 4.36E-4 | 345.48 | 736.95 |
| Efna1 | Ephrin A1 | 2.11 | 2.61E-6 | 3147.43 | 1260.76 |
| Epha2 | Eph receptor A2 | 1.55 | 1.30E-3 | 962.28 | 519.21 |
| Epha3 | Eph receptor A3 | 2.48 | 7.19E-6 | 423.09 | 142.28 |
| Ephb4 | Eph receptor B4 | 1.58 | 1.78E-5 | 1823.39 | 1154.75 |
| Fzd1 | Frizzled family receptor 1 | 1.61 | 1.57E-4 | 3294.49 | 1737.36 |
| Fzd2 | Frizzled family receptor 2 | 2.30 | 5.65E-5 | 1510.22 | 553.03 |
| Fzd4 | Frizzled family receptor 4 | 2.13 | 1.12E-6 | 27910.91 | 11573.53 |
| Gli1 | GLI family zinc finger 1 | 3.69 | 6.92E-7 | 1546.43 | 352.42 |
| Gli3 | GLI family zinc finger 3 | 1.88 | 7.20E-6 | 875.61 | 391.09 |
| Glis2 | GLIS family zinc finger 2 | 2.40 | 2.61E-6 | 5800.04 | 2071.55 |
| Neo1 | Neogenin 1 | 1.64 | 6.59E-4 | 1993.71 | 1025.67 |
| Ngfr | Nerve growth factor receptor | 3.04 | 1.78E-7 | 1908.67 | 529.36 |
| Ntn1 | Netrin1 | 1.93 | 2.53E-4 | 847.38 | 369.33 |
| Nrp1 | Neuropilin 1 | 1.78 | 2.74E-5 | 2056.64 | 974.00 |
| Nrp2 | Neuropilin 2 | 1.76 | 8.48E-7 | 12442.03 | 6130.56 |
| Ntrk3 | Neurotrophic tyrosine kinase receptor, type 3 | 1.62 | 3.10E-3 | 2443.41 | 1275.19 |
| Plxna3 | Plexin A3 | 1.83 | 8.56E-4 | 342.15 | 156.10 |
| Plxna4 | Plexin A4 | 1.83 | 2.01E-5 | 665.49 | 303.65 |
| Plxnb3 | Plexin B3 | 1.83 | 1.69E-4 | 392.32 | 178.84 |
| Plxnc1 | Plexin C1 | −1.53 | 2.22E-2 | 655.39 | 836.41 |
| Plxnd1 | Plexin D1 | 1.51 | 2.69E-5 | 1811.96 | 1006.60 |
| Sema3c | Semaphorin 3C | 2.64 | 9.06E-4 | 9006.91 | 2944.58 |
| Sema4d | Semaphorin 4D | −1.73 | 1.94E-2 | 1183.27 | 1717.65 |
| Sema5b | Semaphorin 5B | 5.52 | 2.70E-7 | 300.19 | 44.94 |
| Slitrk6 | Slit and Ntrk-like family, member 6 | 5.01 | 1.53E-6 | 303.93 | 50.48 |
| Smo | Smoothened, frizzled family receptor | 1.73 | 1.69E-6 | 11376.56 | 5678.09 |
| Srgap1 | Slit-Robo Rho GTPase activating protein 1 | 2.03 | 1.10E-3 | 239.78 | 98.54 |
| Tuba1a | Tubulin, α 1a | 2.98 | 1.01E-6 | 86573.28 | 27387.47 |
| Tuba8 | Tubulin, α 8 | −2.59 | 2.26E-3 | 1037.29 | 2270.74 |
| Unc5a | Unc-5 homolog A (C. elegans) | 1.87 | 2.10E-3 | 4363.89 | 1992.32 |
| Unc5b | Unc-5 homolog B (C. elegans) | 2.71 | 4.10E-8 | 3761.43 | 1171.69 |
The expression of the chosen genes with an absolute FC > 1.5 (n = 8 mice/group) is shown. Fold change difference was generated based on normalized signals obtained from mice reared at 29°C (data not shown).