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. 2015 Jul 1;29(13):1343–1355. doi: 10.1101/gad.262766.115

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© 2015 Yue et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 1. — Illustration of the cellular pathways of m⁶A in nuclear RNAs. The m⁶A methyltransferases and demethylases dynamically control the m⁶A methylation landscape within the nucleus. The m⁶A reader proteins preferentially bind to the methylated RNA and mediate specific functions. In the nucleus, m⁶A may affect alternative splicing of pre-mRNA and mature mRNA storage and export. After mature RNAs are exported to the cytoplasm, cytoplasmic m⁶A reader YTHDF2 can bind to the m⁶A-containing mRNAs to mediate mRNA decay. Other cytoplasmic readers could modulate mRNA translation and storage.