Table 2.
Chromium content of normal rats and type 2 diabetic rats after administration of chromium malate, chromium trichloride and chromium picolinate, and changes in serum and organs
| Group | Parameter | ||||||
|---|---|---|---|---|---|---|---|
| μg/mL | μg/g | ||||||
| Serum | Heart | Liver | Spleen | Lung | Kidney | Brain | |
| Normal control group | 15.28 ± 1.06 | 6.29 ± 2.01 | 5.97 ± 2.12 | 10.45 ± 2.49 | 14.54 ± 2.01 | 9.32 ± 2.27 | 9.98 ± 2.27 |
| Model group | 10.01 ± 1.05† | 5.91 ± 1.38 | 5.88 ± 1.24 | 9.74 ± 2.75 | 13.98 ± 2.92 | 7.58 ± 2.50 | 8.59 ± 2.13 |
| Chromium trichloride-treated group | 12.03 ± 1.13† | 5.93 ± 2.17 | 6.01 ± 2.19 | 11.00 ± 3.62 | 13.06 ± 4.30 | 8.64 ± 3.06 | 9.46 ± 3.27 |
| Chromium picolinate-treated group | 17.14 ± 1.51‡§ | 7.12 ± 4.28 | 5.84 ± 1.87 | 11.97 ± 4.19 | 14.56 ± 4.31 | 10.37 ± 3.24 | 10.58 ± 3.25 |
| Chromium malate-treated group 1 | 10.47 ± 1.27†¶ | 5.30 ± 2.23 | 5.84 ± 2.58 | 9.86 ± 2.59 | 13.91 ± 2.67 | 7.93 ± 2.48 | 8.51 ± 2.02 |
| Chromium malate-treated group 2 | 10.94 ± 1.47†¶ | 5.72 ± 2.14 | 5.97 ± 1.98 | 9.92 ± 3.01 | 13.98 ± 2.64 | 8.55 ± 2.30 | 8.69 ± 2.85 |
| Chromium malate-treated group 3 | 11.01 ± 1.05†¶ | 6.02 ± 2.01 | 5.91 ± 2.24 | 10.06 ± 3.21 | 13.98 ± 3.82 | 8.99 ± 3.01 | 8.82 ± 3.02 |
| Chromium malate-treated group 4 | 11.25 ± 1.34†¶ | 6.18 ± 2.26 | 5.95 ± 2.33 | 10.58 ± 3.51 | 14.12 ± 2.52 | 9.49 ± 2.15 | 9.03 ± 2.34 |
| Chromium malate-treated group 5 | 13.77 ± 1. 29¶ | 6.50 ± 2.12 | 5.97 ± 2.56 | 11.36 ± 3.90 | 14.15 ± 3.92 | 10.01 ± 2.59 | 9.20 ± 3.09 |
| Chromium malate-treated group 6 | 16.42 ± 1.65‡§ | 6.63 ± 2.48 | 6.00 ± 3.53 | 13.36 ± 5.04 | 14.22 ± 4.43 | 10.48 ± 3.43 | 10.04 ± 3.21 |
| Chromium malate-treated group 7 | 17.04 ± 1.53‡§ | 7.16 ± 3.47 | 6.00 ± 2.62 | 14.55 ± 3.37 | 14.39 ± 3.21 | 10.76 ± 3.41 | 10.21 ± 3.35 |
| Chromium malate-treated group 8 | 17.68 ± 1.35‡§ | 7.91 ± 3.14 | 6.03 ± 2.21 | 15.58 ± 4.53 | 14.59 ± 4.03 | 11.00 ± 3.62 | 10.34 ± 3.41 |
| Chromium malate-treated group 9 | 17.98 ± 1.17‡§ | 8.09 ± 3.54 | 6.06 ± 1.29 | 16.09 ± 5.21 | 14.60 ± 5.01 | 11.02 ± 4.23 | 10.82 ± 4.05 |
| Chromium malate control group | 15.45 ± 1.24‡§ | 6.39 ± 2.10 | 5.97 ± 2.67 | 12.31 ± 4.53 | 14.41 ± 4.86 | 10.69 ± 4.41 | 11.26 ± 4.16 |
Data is presented as mean ± standard deviation (n = 10). Chromium trichloride and chromium picolinate were used as positive controls.
†
Significantly different from normal control group (P < 0.05).
‡
Significantly different from model group (P < 0.05).
§
Significantly different from chromium trichloride-treated group (P < 0.05).
¶
Significantly different from chromium picolinate-treated group (P < 0.05).