Table 3.
Biochemical analyses in normal rats and type 2 diabetic rats after administration of chromium malate, chromium trichloride and chromium picolinate
| Group | Parameter | |||||
|---|---|---|---|---|---|---|
| ALT (IU/L) | AST (IU/L) | ALP (IU/L) | TP (g/L) | BUN (mmol/L) | Crea (μmol/L) | |
| Normal control group | 45.28 ± 6.36 | 95.29 ± 11.72 | 155.57 ± 28.95 | 67.92 ± 5.46 | 4.45 ± 0.77 | 33.90 ± 7.12 |
| Model group | 41.11 ± 5.11 | 121.53 ± 34.38 | 242.83 ± 30.42† | 70.24 ± 1.17 | 5.82 ± 0.58† | 45.85 ± 9.05 |
| Chromium trichloride-treated group | 47.13 ± 8.89 | 123.63 ± 17.48 | 243.33 ± 29.91† | 71.00 ± 2.16 | 5.90 ± 0.13 | 41.65 ± 6.20 |
| Chromium picolinate-treated group | 40.41 ± 5.21 | 120.30 ± 14.28 | 224.20 ± 37.88† | 69.77 ± 1.96 | 5.67 ± 0.36 | 37.88 ± 4.21 |
| Chromium malate-treated group 1 | 44.71 ± 7.17 | 124.77 ± 19.32 | 231.00 ± 31.85† | 69.66 ± 2.35 | 6.11 ± 0.74† | 43.80 ± 4.88 |
| Chromium malate-treated group 2 | 45.83 ± 7.17 | 120.78 ± 29.41 | 234.67 ± 20.98† | 71.00 ± 2.65 | 5.99 ± 0.76† | 43.33 ± 4.20 |
| Chromium malate-treated group 3 | 49.25 ± 5.08 | 102.72 ± 11.36 | 230.00 ± 28.76† | 68.76 ± 2.13 | 5.88 ± 0.82† | 40.37 ± 3.67 |
| Chromium malate-treated group 4 | 46.50 ± 9.99 | 105.78 ± 26.27 | 214.75 ± 21.36 | 69.78 ± 1.78 | 5.81 ± 0.25 | 40.05 ± 5.63 |
| Chromium malate-treated group 5 | 47.70 ± 9.82 | 110.00 ± 12.27 | 211.75 ± 13.65 | 68.83 ± 2.04 | 5.57 ± 0.39 | 35.18 ± 2.43 |
| Chromium malate-treated group 6 | 46.42 ± 6.55 | 106.03 ± 18.45 | 211.67 ± 19.35 | 68.33 ± 3.06 | 5.62 ± 0.44 | 35.86 ± 3.13 |
| Chromium malate-treated group 7 | 45.84 ± 7.39 | 107.56 ± 10.47 | 206.33 ± 26.26 | 68.50 ± 1.73 | 5.52 ± 1.12 | 36.78 ± 6.94 |
| Chromium malate-treated group 8 | 49.30 ± 7.55 | 100.83 ± 14.53 | 201.75 ± 18.01 | 68.67 ± 2.03 | 5.65 ± 0.22 | 35.58 ± 3.70 |
| Chromium malate-treated group 9 | 48.58 ± 7.02 | 103.38 ± 15.45 | 196.00 ± 19.29 | 68.25 ± 4.44 | 5.20 ± 0.42 | 34.10 ± 3.29 |
| Chromium malate control group | 48.15 ± 7.45 | 93.33 ± 10.25 | 152.92 ± 17.60‡§¶ | 67.74 ± 3.94 | 4.01 ± 0.68‡ | 29.78 ± 1.74 |
Data is presented as mean ± standard deviation (n = 10). Chromium trichloride and chromium picolinate were used as positive controls.
ALT, alanine transaminase
ALP, alkaline phosphatase
AST, aspartate transaminase
BUN, blood urea nitrogen
Crea, creatinine
TP, total protein.
†
Significantly different from normal control group (P < 0.05).
‡
Significantly different from model group (P < 0.05).
§
Significantly different from chromium trichloride-treated group (P < 0.05).
¶
Significantly different from chromium picolinate-treated group (P < 0.05).