Table 5.

Multivariate analysis of prognostic factors

Predictor factor	RR	95% CI of RR	P value
Age	0.986	0.965–1.007	0.188
Gender	1.040	0.683–1.585	0.854
Histology	1.048	0.604–1.818	0.867
ECOG PS	0.210	0.111–0.399	0.000
Time between NSCLC and LM	0.808	0.596–1.097	0.172
WBRT	0.588	0.375–0.920	0.020
SC	0.842	0.574–1.392	0.273
EGFR-TKIs	0.215	0.125–0.371	0.000

ECOG PS, Eastern Cooperative Oncology Group performance status

EGFR-TKIs, epidermal growth factor receptor tyrosine kinase inhibitors

LM, leptomeningeal metastases

NSCLC, non-small cell lung cancer

RR, relative risk

SC, systemic chemotherapy

WBRT, whole brain radiotherapy.