Table 1.
The significantly enriched Kyoto Encyclopedia of Genes and Genomes pathways of differentially expressed genes in the treatment groups compared with the control groups
| Term | Count | P-value | Genes |
|---|---|---|---|
| Upregulated genes | |||
| hsa03410:Base excision repair | 4 | 3.48E-03 | POLL, MUTYH, PCNA, PARP3 |
| hsa04630:Jak-STAT signaling pathway | 5 | 4.70E-02 | AKT1, CLCF1, STAT5A, IL15RA, STAT2 |
| Downregulated genes | |||
| hsa04150:mTOR signaling pathway | 5 | 2.19E-04 | MAPK1, HIF1A, VEGFA, PRKAA1, MLST8 |
| hsa04370:VEGF signaling pathway | 5 | 8.95E-04 | MAPK1, PTK2, MAPK14, VEGFA, PPP3CC |
| hsa05412:Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 4 | 9.75E-03 | DMD, CACNG6, DAG1, TCF7L2 |
| hsa05410:Hypertrophic cardiomyopathy (HCM) | 4 | 1.32E-02 | DMD, CACNG6, DAG1, PRKAA1 |
| hsa04010:MAPK signaling pathway | 6 | 1.86E-02 | MAPK1, ARRB2, MAPK14, CACNG6, PPP3CC, NFKB1 |
| hsa04660:T cell receptor signaling pathway | 4 | 2.50E-02 | MAPK1, MAPK14, PPP3CC, NFKB1 |
| hsa04722:Neurotrophin signaling pathway | 4 | 3.56E-02 | MAPK1, MAPK14, NFKB1, SH2B1 |
| hsa05200:Pathways in cancer | 6 | 4.07E-02 | MAPK1, PTK2, HIF1A, VEGFA, NFKB1, TCF7L2 |
| hsa05221:Acute myeloid leukemia | 3 | 4.54E-02 | MAPK1, NFKB1, TCF7L2 |
Count, the number of genes enriched on the term.
AKT1, v-akt murine thymoma viral oncogene homolog 1 (ID: 207)
ARRB2, arrestin, beta 2 (ID: 409)
CACNG6, calcium channel, voltage-dependent, gamma subunit 6 (ID: 59285)
CLCF1, cardiotrophin-like cytokine factor 1 (ID: 23529)
DAG1, dystroglycan 1 (ID: 1605)
DMD, dystrophin, muscular dystrophy (ID: 1756)
HIF1A, hypoxia inducible factor 1, alpha subunit (ID: 3091)
IL15RA, interleukin 15 receptor, alpha chain (ID: 3601)
MAPK1, mitogen-activated protein kinase 1 (ID: 5594)
MAPK14, mitogen-activated protein kinase 14 (ID: 1432)
MLST8, MTOR associated protein, LST8 homolog (ID: 64223)
MUTYH, mutY homolog (ID: 4595)
NFKB1, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (ID: 4790)
PARP3, poly (ADP-ribose) polymerase family, member 3 (ID: 10039)
PCNA, proliferating cell nuclear antigen (ID: 5111)
POLL, polymerase (DNA directed), lambda (ID: 27343)
PRKAA1, protein kinase, AMP-activated, alpha 1 catalytic subunit (ID: 5562)
PTK2, protein tyrosine kinase 2 (ID: 5747)
PPP3CC, protein phosphatase 3, catalytic subunit, gamma isozyme (ID: 5533)
STAT2, signal transducer and activator of transcription 2, 113 kDa (ID: 6773)
STAT5A, signal transducer and activator of transcription 5A (ID: 6776)
SH2B1, SH2B adaptor protein 1 (ID: 25970)
TCF7L2, transcription factor 7-like 2 (ID: 6934)
VEGFA, vascular endothelial growth factor A (ID: 7422).