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Collagen 4 immunohistochemistry of a psoriatic plaque (A), distant uninvolved skin (B), and treated skin (C). (A) Immunohistochemistry revealed the bi-layer aspect of the basal membrane in the psoriatic plaque (arrow heads). Focally, the continuity of the basal membrane was interrupted (double arrows). This aspect is different from the single line continuum of the distant uninvolved skin (B) and treated skin (C). Black arrows indicate blood vessels. Magnification 200×.
