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S100 immunohistochemistry of a psoriatic plaque (A) reveals an increased density of S100-positive Langerhans cells (arrow heads) beneath the basal membrane of the epidermis, and just a few positive Langerhans cells in the epidermis. In both distant uninvolved skin (B) and treated skin (C), S100-positive Langerhans cells (arrow heads) are situated in the epidermis. Black arrows indicate blood vessels. Magnification 200×.
