Table 3.
Results of A>G (rs553668) and C>G (rs1800544) genotyping analysis and their association with BMD and biochemical markers of bone turnover in subgroups of subjects
| A>G (%) | C>G (%) | A>G (rs553668) | C>G (rs1800544) | |
|---|---|---|---|---|
| Premenopausal women | G/G 37 (69.8) | C/C 28 (52.8) | Cathepsin K (P = 0.014) | NS |
| G/A 16 (30.2) | C/G 22 (41.5) | AG: 18.3 ± 19.2 pmol/l | ||
| A/A 0 (0) | G/G 3 (5.7) | GG: 3.5 ± 19.1 pmol/l | ||
| Postmenopausal women | G/G 307 (71.6) | C/C 257 (59.9) | NS | BMD-ls (P = 0.027) |
| G/A 114 (26.6) | C/G 147 (34.3) | GG: 0.802 ± 0.155 g/cm2 | ||
| A/A 8 (1.9) | G/G 25 (5.8) | GC: 0.880 ± 0.157 g/cm2 | ||
| Elderly men | G/G 87 (80.6) | C/C 79 (73.1) | NS | sCTX (P = 0.012) |
| G/A 20 (18.5) | C/G 26 (24.1) | GC: 3305 ± 988 pmol/l | ||
| A/A 1 (0.9) | G/G 3 (2.8) | CC: 1689 ± 949 pmol/l | ||
| OP patients | G/G 60 (84.5) | C/C 49 (69.0) | pOC (P = 0.009) | sBALP (P = 0.053) |
| G/A 10 (14.1) | C/G 21 (29.6) | AG: 11.8 ± 5.2 μg/l | GC: 9.6 ± 2.9 μg/l | |
| A/A 1 (1.4) | G/G 1 (1.4) | GG: 5.4 ± 5.2 μg/l | CC: 7.2 ± 2.9 μg/l |
Values are number of frequencies (percentages) and mean ± SD. Differences were obtained using general linear model.
NS, P > 0.05.
BMD-ls, lumbar spine bone mineral density; sCTX, serum C-terminal crosslinking telopeptides of type I collagen; pOC, plasma osteocalcin; sBALP, serum bone alkaline phosphatase concentration; cathepsin K, serum cathepsin K concentration.