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Effect of p53 on gypenoside-induced A549 growth inhibition. (A) A549 cell survival in the presence or absence of gypenosides (30 or 100 μg/ml), pifithrin-α (PFTα, a p53 inhibitor, 25 or 50 μM) and p53-shRNA (clone #4, 5 and 7). (B) Cellular p53 protein levels in four independent A549 clones stably transfected with anti-p53-shRNA.
