Table 1. Confocal-based LCS measurements—compartmental comparisons.
| C57BL/6J Mice (15 w) |
C57BL/6J Mice (32 w) |
C1532Yneo perlecan hypomorph Mice (32 w) |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Measurement/Unit | Cortical | Cancellous | Difference | Cortical | Cancellous | Difference | Cortical | Cancellous | Difference |
| No. of lacuna. | 30 | 30 | 30 | 30 | 30 | 30 | |||
| Lacunar volume/μm3 | 449.7 ± 173.7 | 400.9 ± 133.1 | –10.8% P=0.23 | 447.2 ± 209.4 | 399.7 ± 141.1 | –10.7% P=0.31 | 368.6 ± 168.7 | 305.4 ± 150.4 | –17.1% P=0.13 |
| Lacunar surface Area/μm2 | 410.0 ± 108.0 | 384.7 ± 95.3 | –6.3% P=0.34 | 390.8 ± 120.4 | 350.4 ± 88.0 | –10.3% P=0.14 | 347.7 ± 97.4 | 316.5 ± 126.3 | –8.9% P=0.29 |
| Lac. major axis/μm | 15.8 ± 2.9 | 12.8 ± 2.5 | –18.9% P<0.001 | 16.5 ± 3.7 | 13.6 ± 3.6 | –17.6% P=0.003 | 15.4 ± 3.7 | 12.3 ± 2.8 | –20.1% P=0.000 5 |
| Lacunar density /μm–2 | 1 200.7 ± 149.0 | 1 078.2 ± 213.9 | –10.2% P=0.01 | 1 103.9 ± 187.1 | 1 049.9 ± 239.0 | –4.9% P=0.33 | 1 075.5 ± 185.3 | 1 010.5 ± 253.7 | –6.0% P=0.26 |
| Canalicular No. | 73.8 ± 20.1 | 68.3 ± 13.0 | –7.5% P=0.21 | 77.5 ± 12.0 | 67.3 ± 8.8 | –13.2% P<0.001 | 65.3 ± 15.2 | 59.3 ± 17.2 | –9.2% P=0.16 |
| Canalicular No. Density /μm–2 | 0.209 ± 0.048 | 0.210 ± 0.050 | 0.5% P=0.94 | 0.209 ± 0.043 | 0.200 ± 0.039 | –4.3% P=0.40 | 0.190 ± 0.020 | 0.190 ± 0.020 | P>0.99 |
Note: Difference represented difference between compartments and it was calculated as (Cancellous-Cortical)/Cortical.