Table 8. TEM-Based LCS Measurements—Effects of Diabetes.
| C57BL/6J WT mice (20 w) | C57BL/6-Ins2Akita/J Adult Akita (20 w) | ||
|---|---|---|---|
| Measurement/Unit | Cortical | Cortical | Difference/%-(Akita-WT)/WT |
| No. of lacuna | 68 | 69 | |
| Lac. pericellualr area/μm2 | 2.97 ± 1.74 | 3.78 ± 3.03 | 27.3% P=0.06 |
| Lac. pericellular thickness/μm | 0.23 ± 0.14 | 0.28 ± 0.21 | 21.7% P=0.10 |
| No. of Canaliculi | 206 | 211 | |
| Canalicular area/μm2 | 0.059 ± 0.023 | 0.054 ± 0.019 | –8.5% P=0.02 |
| Cell process area/μm2 | 0.015 ± 0.007 | 0.013 ± 0.006 | –13.3% P<0.005 |
| Can. pericellular area/μm2 | 0.045 ± 0.018 | 0.042 ± 0.015 | –6.7% P=0.06 |
| Can. pericellular thickness/μm | 0.079 ± 0.020 | 0.078 ± 0.018 | –1.3% P=0.59 |
Note: Measurements were made on 20-weeks-old C57BL/6J (WT) and C57BL/6-Ins2Akita/J (Akita) male mice (three animals per group).