Table 2.
Participant Characteristics by Quartile of FEV1/FVC Ratio Decline
| Quartile of Decline in FEV1/FVC Ratio |
P Value | ||||
|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | ||
| N | 750 | 750 | 750 | 750 | |
| FEV1/FVC decline, % | 1.09 ± 0.98 | 4.08 ± 0.78 | 6.69 ± 0.81 | 12.06 ± 4.29 | |
| FEV decline, L | 0.52 ± 0.28 | 0.56 ± 0.28 | 0.59 ± 0.28 | 0.71 ± 0.38 | |
| FVC decline, L | 0.68 ± 0.36 | 0.58 ± 0.35 | 0.50 ± 0.33 | 0.45 ± 0.39 | |
| Demographics | |||||
| Sex (male), n | 408 | 342 | 274 | 249 | |
| Age, Year 25 examination | 50.66 ± 3.48 | 50.36 ± 3.60 | 50.03 ± 3.64 | 49.84 ± 3.67 | |
| BMI, kg/m2 | 32.43 ± 7.38 | 30.78 ± 7.32 | 29.24 ± 6.64 | 27.71 ± 6.09 | |
| Height, cm | 171.87 ± 9.82 | 170.41 ± 9.52 | 169.25 ± 9.28 | 169.42 ± 8.77 | |
| Waist girth, cm | 100.90 ± 15.51 | 95.76 ± 16.03 | 91.45 ± 14.70 | 88.09 ± 13.88 | |
| Race, n | |||||
| White | 402 | 420 | 443 | 400 | |
| African American | 348 | 330 | 307 | 350 | |
| Smoking status, n | |||||
| Never | 479 | 486 | 450 | 453 | |
| Former | 164 | 151 | 192 | 137 | |
| Current | 98 | 101 | 97 | 151 | |
| Peak lung function | |||||
| Age peak FEV1, yr | 28.43 ± 4.72 | 28.02 ± 4.45 | 27.47 ± 4.40 | 27.03 ± 4.06 | |
| Peak FEV1, L | 3.73 ± 0.82 | 3.68 ± 0.81 | 3.61 ± 0.78 | 3.55 ± 0.76 | |
| Age peak FVC, yr | 28.79 ± 4.70 | 29.72 ± 5.02 | 29.97 ± 5.28 | 30.83 ± 5.80 | |
| Peak FVC, L | 4.65 ± 1.08 | 4.51 ± 1.07 | 4.37 ± 1.01 | 4.25 ± 0.95 | |
| Age peak FEV1/FVC ratio, yr | 33.95 ± 9.21 | 27.78 ± 4.78 | 26.73 ± 4.54 | 26.44 ± 4.40 | |
| Peak FEV1/FVC ratio | 82.51 ± 5.68 | 83.82 ± 5.36 | 85.10 ± 5.40 | 87.17 ± 6.88 | |
| LV size parameters | |||||
| LV end-diastolic volume, ml (2D) | 117.70 ± 30.54 | 113.09 ± 29.80 | 110.01 ± 27.52 | 103.91 ± 26.75 | <0.0001 |
| LV end-systolic volume, ml (2D) | 46.49 ± 18.27 | 44.37 ± 16.77 | 42.58 ± 15.30 | 40.11 ± 14.49 | <0.0001 |
| LA internal dimension, cm (M-mode) | 3.85 ± 0.49 | 3.76 ± 0.48 | 3.64 ± 0.46 | 3.57 ± 0.49 | <0.0001 |
| LV hypertrophy parameters | |||||
| LV posterior wall thickness, diastole, cm | 0.93 ± 0.15 | 0.90 ± 0.17 | 0.87 ± 0.16 | 0.85 ± 0.17 | <0.0001 |
| Interventricular septal wall, diastole, cm | 0.95 ± 0.16 | 0.91 ± 0.17 | 0.89 ± 0.16 | 0.87 ± 0.17 | <0.0001 |
| LV mass, g (M-mode) | 183.46 ± 50.82 | 172.11 ± 55.38 | 162.54 ± 48.65 | 152.06 ± 47.11 | <0.0001 |
| LV function parameters | |||||
| LV ejection fraction, % (M-mode) | 69.48 ± 8.40 | 69.77 ± 8.23 | 69.51 ± 7.53 | 70.13 ± 7.76 | 0.40 |
| LV stroke volume, ml (M-mode) | 92.69 ± 21.81 | 90.07 ± 23.22 | 87.04 ± 20.25 | 83.28 ± 20.69 | <0.0001 |
| Heart rate, bpm | 66.12 ± 10.54 | 65.05 ± 10.83 | 64.92 ± 10.94 | 65.36 ± 10.59 | 0.17 |
| LV cardiac output, L/min | 6.09 ± 1.56 | 5.84 ± 1.75 | 5.62 ± 1.49 | 5.41 ± 1.46 | <0.0001 |
| LV E wave, cm/s | 76.85 ± 16.77 | 78.42 ± 16.01 | 79.79 ± 14.93 | 79.90 ± 15.32 | 0.0004 |
| LV A wave, cm/s | 63.97 ± 16.77 | 64.28 ± 17.03 | 62.81 ± 16.05 | 63.35 ± 15.70 | 0.32 |
| LV E/A ratio | 1.26 ± 0.36 | 1.28 ± 0.34 | 1.34 ± 0.39 | 1.32 ± 0.36 | <0.0001 |
Definition of abbreviations: 2D = two-dimensional; BMI = body mass index; LA = left atrial; LV = left ventricular.
Data reported as mean ± SD.