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Hypothetical models of insulin-like and DA pathways in the control of diapause, longevity, and gonadal migration. A. HSD-1 and DAF-36 act in canonical DA biosynthetic pathways to promote reproductive development. B. HSD-1 does not participate in lifespan control by the germline pathway but promotes lifespan extension in animals with reduced insulin-like signaling. C. Regulation of gonadal migration does not require HSD-1.
