. Author manuscript; available in PMC: 2015 Aug 1.

Published in final edited form as: Mol Neurobiol. 2014 Apr 6;50(1):239–245. doi: 10.1007/s12035-014-8690-0

TABLE 1.

Effect of intermittent severe binge alcohol intoxication on levels of neuroinflammatory proteins and oxidative stress footprints (4-hydroxynonenal-protein adducts) in brain regions of adult male rats: Majchrowicz protocol (% of gavage control values ± sem)

Brain Region	cPLA2	p-cPLA2	sPLA2	iPLA2	AQP4	PARP-1	HNE-adducts
HC^¶	^*225±45	^*155±10	^*180±	^*65±10	^*170±16	^*235±40	^*150±26
EC^¶	^*180±20	^*165±15	^*255±	nc	^*210±25	^*230±35	^*195±22
OB^¶	^*240±65	^*225±50	^**340±	nc	^*175±27	^*250±45	nd
FC^¶	nc	nc	nc	nc	nc	nc	nd
CB^¶	nc	nc	nc	nc	nc	nc	nd

Values from immunoblots with GAPDH loading controls (Tajuddin et al., PLoS ONE, accepted for publication).

HC=hippocampus; EC=entorhinal cortex; OB=olfactory bulb; FC=frontal cortex; CB=cerebellum; HNE=4-hydroxynonenal.

^¶

Brain region incurring established and measurable neurodegeneration in this model; (n=4–7 rats/group).

p<0.05 vs. control;

^**

p<0.01 vs. control;

nc, no significant change vs. control; nd, not determined.