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. 2015 Jul 22;10(7):e0132672. doi: 10.1371/journal.pone.0132672

Fig 6. Soybean oil causes a distinct dysregulation of hepatic gene expression from coconut oil.

Fig 6

A) Principle components analysis (PCA) of RNA-seq from livers of male mice fed Viv, HFD or SO-HFD for 35 weeks showing the three biological replicates clustering together for each diet except for one HFD outlier. B) Heat map showing differential gene expression between SO-HFD, HFD and Viv livers. C) Venn diagrams showing genes dysregulated in HFD or SO-HFD versus Viv. D) Increased Cidea mRNA expression confirmed by qPCR in the livers of mice fed SO-HFD compared to mice fed Viv or HFD for 16 or 35 weeks. * SO-HFD (35 weeks) is significantly higher than all others. Significance is defined as P ≤ 0.05 using a Student’s t-test. Three livers were assayed in triplicate for all conditions except Viv, for which two livers were analyzed. See S1 Dataset for raw cycle count (Cq) values obtained by qPCR for Cidea and cyclophilin A.