Table 4. Univariate and Multivariate Cox regression analyses for PFS and OS.
| Variables | Progression-free survival | Overall survival | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | ||||||
| HR (95% CI) | P-values | HR (95% CI) | P-values | HR (95% CI) | P-values | HR (95% CI) | P-values | ||
| Age | ≤ 64 | 1 | 0.141 | - | - | 1 | 0.894 | - | - |
| > 65 | 0.63 (0.34–1.17) | 0.96 (0.53–1.76) | |||||||
| Sex | Female | 1 | 0.074 | 1 | 0.051 | 1 | 0.044 | 1 | 0.013 |
| Male | 0.50 (0.23–1.07) | 2.60 (1.00–6.78) | 2.25 (1.02–4.97) | 3.15 (1.27–7.76) | |||||
| ECOG PS | 0–1 | 1 | 0.045 | 1 | 0.045 | 1 | 0.007 | 1 | 0.018 |
| > 1 | 2.39 (1.13–5.05) | 2.21 (1.02–4.81) | 2.72 (1.32–5.63) | 2.62 (1.18–5.81) | |||||
| Primary origin | Urinary bladder | 1 | 0.120 | - | - | 1 | 0.185 | - | - |
| Renal pelvis | 0.63 (0.32–1.24) | 0.57 (0.28–1.14) | |||||||
| Ureter | 0.33 (0.10–1.11) | 0.54 (0.19–1.53) | |||||||
| Visceral metastases | Absent | 1 | 0.040 | 1 | 0.012 | 1 | 0.251 | 1 | 0.045 |
| Present | 1.92 (1.03–3.58) | 2.32 (1.20–4.49) | 1.43 (0.78–2.61) | 1.96 (1.01–3.77) | |||||
| Previous surgery | Yes | 1 | 0.202 | - | - | 1 | 0.141 | - | - |
| No | 1.48 (0.81–2.72) | 1.56 (0.86–2.82) | |||||||
| Chemotherapy regimen | Gem+Cis | 1 | 0.034 | 1 | 0.069 | 1 | 0.213 | - | - |
| Gem+Carbo | 2.01 (1.05–3.83) | 2.13 (0.94–4.79) | 1.48 (0.80–2.76) | ||||||
| RRM1 | Low | 1 | 0.008 | 1 | 0.046 | 1 | 0.008 | 1 | 0.003 |
| High | 2.64 (1.29–5.38) | 2.41 (1.02–5.72) | 2.52 (1.28–4.98) | 3.21 (1.49–6.92) | |||||
| ERCC1 | Low | 1 | 0.100 | 1 | 0.061 | 1 | 0.445 | - | - |
| High | 1.67(0.91–3.07) | 2.14 (0.97–4.75) | 1.26 (0.70–2.26) | ||||||