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Insulin signaling in mammalian cells and in C. elegans. See text for further details. Right panel: C. elegans transgenic strain TJ356 stably expresses a DAF-16::GFP fusion protein. DAF-16::GFP accumulates in nuclei upon exposure of worms to an oxidative stress (induced by diamide, a thiol oxidizing agent). Speckles (arrow) represent nuclei with DAF-16::GFP.
