Fig. 5.

Effects of radiation, cisplatin and GSNO and their combinations on tumor growth in HNSCC xenografted mice. (A) Nude mice were injected with luciferase labeled SCC14a cells (10⁶) and the tumor growth was evaluated by fluorescence intensity after 6 weeks of treatments with the respective protocol. (B) The animals were treated with radiation, cisplatin, and/or GSNO 4 weeks after inoculation of cancer cells, and the time-course changes in tumor size (fluorescence intensity) were measured. To investigate the reversibility in GSNO-inhibited tumor growth, GSNO treatment was discontinued for a group mice treated with cisplatin and radiation after 7 weeks (solid red diamond). The data are mean±standard error from six animals in each group.