. Author manuscript; available in PMC: 2015 Jul 22.

Published in final edited form as: J Magn Reson Imaging. 2009 May;29(5):1071–1079. doi: 10.1002/jmri.21737

Table 1. Histology and Immunohistochemistry.

Groups	Cell density index^a	Significance^b	Apoptotic index^c	Significance^b
Controls	0.242 ± 0.014		0.0341 ±0.003
Daily dose	0.166 ± 0.009	P < 0.050	0.0344 ± 0.004	P > 0.050
Pulsed dose	0.145 ± 0.008	P < 0.050	0.0321 ± 0.004	P > 0.050

A cell density index derived from H&E slides as the ratio of the area occupied by cells in a given field to the total field area, revealed that both gefitinib treatment groups were significantly less dense than the control group. Means and standard error are provided for each group in the gefitinib treatment study.

P-values reflect difference from controls.

An apoptotic index derived from caspase-3-stained slides as the ratio of apoptosis stained cells in a given field to the total number of cells in the field, revealed no significant differences in apoptosis between groups in the gefitinib treatment study.