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. 2015 Jun 17;13(2):91–102. doi: 10.1016/j.gpb.2015.03.006

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© 2015 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Responses of Akt/mTOR signaling to daily torpor in skeletal muscle of gray mouse lemurs

The relative phosphorylation of multiple target proteins in the skeletal muscles was assessed for IGF-1R (Tyr1135/Tyr1136), IR (Tyr1162/Tyr1163), IRS1 (Ser312), PTEN (Ser380), Akt (Ser473), GSK3α (Ser21), GSK3β (Ser9), TSC2 (Ser939), mTOR (Ser2448), p70S6K (Thr412), and RPS6 (Ser235/Ser236) comparing control (aroused) and torpor states. The relative MFI for a given protein in a sample was calculated by normalizing all samples to controls. Data are presented as mean ± SEM (n = 4 independent protein isolations from different animals). * Denotes significant difference from the corresponding control according to the two-tailed Student’s t-test (P < 0.01). MFI, median fluorescent intensity.