Figure 3.
Responses of Akt/mTOR signaling to daily torpor in heart of gray mouse lemurs
The relative phosphorylation of multiple target proteins in heart was assessed for IGF-1R (Tyr1135/Tyr1136); IR (Tyr1162/Tyr1163), IRS1 (Ser312), PTEN (Ser380), Akt (Ser473), GSK3α (Ser21), GSK3β (Ser9), TSC2 (Ser939), mTOR (Ser2448), p70S6K (Thr412), and RPS6 (Ser235/Ser236) comparing control (aroused) and torpor states. Data were obtained and analyzed similarly as indicated in Figure 2. * Denotes significant difference from the corresponding control according to the two-tailed Student’s t-test (P < 0.05).