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. 2015 Jun 17;13(2):91–102. doi: 10.1016/j.gpb.2015.03.006

Figure 3.

Figure 3

Responses of Akt/mTOR signaling to daily torpor in heart of gray mouse lemurs

The relative phosphorylation of multiple target proteins in heart was assessed for IGF-1R (Tyr1135/Tyr1136); IR (Tyr1162/Tyr1163), IRS1 (Ser312), PTEN (Ser380), Akt (Ser473), GSK3α (Ser21), GSK3β (Ser9), TSC2 (Ser939), mTOR (Ser2448), p70S6K (Thr412), and RPS6 (Ser235/Ser236) comparing control (aroused) and torpor states. Data were obtained and analyzed similarly as indicated in Figure 2. * Denotes significant difference from the corresponding control according to the two-tailed Student’s t-test (< 0.05).