Figure 6. G-to-A RNA editing at position 1003 of the wild allele (T) of c.1093T>A in MVK was detected in a left forearm lesion from F-38.
(A) No allelic expression imbalance was observed in lesional tissue (LT) from F-38. (B) A mutation of c.1003G>A was identified in LT cDNA, but not in neighboring normal-appearing skin (NNS) cDNA or LT gDNA. (C) Sequencing the c.1093A and c.1093T allele-specific PCR products indicated the mutant allele(A) of c.1003G>A was in the cis position with the wild allele(T) of c.1093T>A. A-SPCR, c.1093A–specific PCR; T-SPCR, c.1093T-specific PCR.