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. 2015 Jul 23;9:98. doi: 10.3389/fnana.2015.00098

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Copyright © 2015 Seehaus, Roebroeck, Bastiani, Fonseca, Bratzke, Lori, Vilanova, Goebel and Galuske.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differences between MRI_DT and Hist_ST orientations displayed on an FA map. MRI_DT and Hist_ST orientations are plotted in a color range from green (for orientations that perfectly agree) to red (for orientations that differ by 90°). Bar length reflects the projection length of the diffusion tensor in the sectioning plane. There is a generally good histology-DTI agreement for high FA values, especially in white matter. For lower FA, particularly when entering gray matter, there are three cases: (A) Good agreement in case of predominant radial orientations, (B) Moderate to weak agreement, (C) Perpendicular histology-DT orientedness. Here, voxels are located well within gray matter and run in bands parallel to the cortical surface. Scale bar: 5 mm.