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. 2015 Jul 23;9:255. doi: 10.3389/fnins.2015.00255

Figure 2.

Figure 2

Glial fibrillary acidic protein (GFAP) (red, A,E) for astrocytes and thioflavin-S (green, B,F) staining for Aβ plaques in Alzheimer's disease (A–C), APP/PS1 (E–G), control human (D) and control mouse (H) tissue at 100x (A–H) and 400x (A′–C′,E′–G′) magnification. Astrocytes in the AD tissue are in a motile phagocytic state and surround the coronal region of the Aβ plaques. In human control tissue, the astrocytes are observed in their normal highly branched form indicative of their supportive roll for neuronal tissue. APP/PS1 and mouse control tissue similarly stain positive for GFAP throughout the tissue samples and illustrate astrocytes in a highly branched normal supportive role. The strong association seen between astrocytes and Aβ plaques in the AD tissue is not seen in the transgenic model. The data indicates a differential astrocytic inflammatory response to Aβ plaques in the natural AD milieu compared to the transgenic model. The scale bars are standardized to 100 and 25 μm.