Figure 7.

Antibody stains for Aβ₄₂ (red) and thioflavin-S (green) of Alzheimer's disease (A–C) and APP/PS1 (D–F) cortical tissue viewed at 40x (A–F) and 100x (A′–F′) magnification. Alzheimer's samples show positive Aβ₄₂ staining in the core and coronal regions of the plaques as well as intracellularly throughout the microscopic field. The antibody stains indicate that the core and coronal regions of the Alzheimer's plaques are composed of both 40 and 42 amino-acid variants; see Figure 6 for comparison. The APP/PS1 tissue stained minimally for intracellular Aβ₄₂, which was not associated with transgenic plaques. The Aβ stains indicate that APP/PS1 plaques are composed primarily of the 40 amino-acid constituent. Scale bar is calibrated to 100 and 50 μm.