Table 2. Association between Quality of Life Measures and Survival.
| Unadjusted* | Adjusted*† | |||
|---|---|---|---|---|
|
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| QoL Measure | Hazard Ratio (95% CI) | Likelihood ratio P | Hazard Ratio (95% CI) | Likelihood ratio P |
| FACT-G: Physical well-being | 0.91 (0.66 - 1.24) | 0.541 | 0.95 (0.67 - 1.34) | 0.758 |
|
| ||||
| FACT-G: Functional well-being | 0.79 (0.60 - 1.03) | 0.086 | 0.82 (0.62 - 1.08) | 0.148 |
|
| ||||
| FACT-G: Emotional well-being | 0.89 (0.59 - 1.36) | 0.592 | 0.87 (0.57 - 1.32) | 0.513 |
|
| ||||
| FACT-G: Social well-being | 0.91 (0.65 - 1.29) | 0.612 | 0.93 (0.63 - 1.37) | 0.702 |
|
| ||||
| FACT-G: Total score | 0.94 (0.84 - 1.04) | 0.242 | 0.95 (0.84 - 1.06) | 0.329 |
|
| ||||
| FACT-Br: Brain cancer subscale | 0.88 (0.77 - 1.00) | 0.048 | 0.89 (0.77 - 1.02) | 0.100 |
|
| ||||
| FACT-Br: Total score | 0.95 (0.89 - 1.01) | 0.090 | 0.95 (0.88 - 1.02) | 0.154 |
|
| ||||
| FACT-Br: Trial Outcome Index (TOI) | 0.93 (0.86 - 1.00) | 0.062 | 0.93 (0.85 - 1.02) | 0.124 |
|
| ||||
| FACIT-Fatigue Subscale Score | 0.82 (0.68 - 0.99) | 0.045 | 0.80 (0.65 - 0.98) | 0.031 |
*
All hazard ratios are associated with a 10 unit change in each QoL measure.
†
Adjusted for age, sex, grade, number of prior progressions, and KPS.