Table 4.
Percentage of animals that experienced a decline in rotarod performance at 1 month in Th1(+) and Th17(+) animals. Statistics are by likelihood ratio.
| spleen | lymph node | ischemic hemisphere | non-ischemic hemisphere | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Th1(−) | Th1(+) | P | Th1(−) | Th1(+) | P | Th1(−) | Th1(+) | P | Th1(−) | Th1(+) | P | |
| rMBP | 7/20 (35%) | 10/17 (59%) | NS | 10/21 (48%) | 7/15 (47%) | NS | 7/15 (47%) | 7/7 (100%) | 0.004 | 0/7 | 7/14 (50%) | 0.007 |
| MBP 68-86 | 9/21 (43%) | 8/16 (50%) | NS | 8/26 (31%) | 9/11 (82%) | 0.004 | 6/10 (60%) | 8/12 (67%) | NS | 4/8 (50%) | 8/14 (57%) | NS |
| MBP 63-81 | 11/23 (48%) | 6/14 (43%) | NS | 8/18 (44%) | 9/19 (47%) | NS | 9/16 (56%) | 5/6 (83%) | NS | 4/8 (50%) | 9/14 (64%) | NS |
| bMBP | 8/19 (42%) | 9/17 (53%) | NS | 10/21 (48%) | 6/13 (46%) | NS | 6/12 (50%) | 8/9 (89%) | 0.05 | 2/7 (29%) | 10/14 (71%) | 0.06 |
| hMBP | 9/18 (50%) | 8/19 (42%) | NS | 12/28 (43%) | 5/9 (56%) | NS | 11/18 (61%) | 3/4 (75%) | NS | 1/8 (12%) | 6/14 (43%) | NS |
| OVA | 9/21 (43%) | 8/16 (50%) | NS | 9/22 (41%) | 5/8 (62%) | NS | 6/12 (50%) | 8/10 (80%) | NS | 3/8 (38%) | 10/14 (71%) | NS |
| Spleen | lymph node | ischemic hemisphere | non-ischemic hemisphere | |||||||||
| Th17(−) | Th17(+) | P | Th17(−) | Th17(+) | P | Th17(−) | Th17(+) | P | Th17(−) | Th17(+) | P | |
| rMBP | 6/18 (33%) | 11/19 (58%) | NS | 14/25 (56%) | 3/10 (30%) | NS | 10/16 (62%) | 4/6 (67%) | NS | 1/8 (12%) | 4/14 (29%) | NS |
| MBP 68-86 | 12/26 (46%) | 5/11 (45%) | NS | 14/27 (52%) | 3/8 (38%) | NS | 10/15 (67%) | 4/7 (57%) | NS | 2/8 (25%) | 6/14 (43%) | NS |
| MBP 63-81 | 9/23 (39%) | 8/14 (57%) | NS | 11/19 (58%) | 6/17 (35%) | NS | 9/14 (64%) | 5/8 (62%) | NS | 1/8 (12%) | 4/14 (29%) | NS |
| bMBP | 11/18 (61%) | 6/18 (33%) | 0.09 | 11/21 (52%) | 5/12 (42%) | NS | 8/13 (62%) | 6/8 (75%) | NS | 1/7 (14%) | 8/14 (57%) | 0.05 |
| hMBP | 10/18 (56%) | 7/19 (37%) | NS | 10/23 (43%) | 7/12 (58%) | NS | 10/15 (67%) | 4/7 (57%) | NS | 1/8 (12%) | 8/14 (57%) | NS |
| OVA | 13/27 (48%) | 4/10 (40%) | NS | 10/21 (48%) | 4/7 (57%) | NS | 7/11 (64%) | 7/11 (64%) | NS | 2/8 (25%) | 9/14 (64%) | 0.07 |
Note: In a subset of animals undergoing MCAO (N=15), brains were removed and frozen. Lymphocytes were thus not available from these brains.
rMBP=rat MBP, bMBP=bovine MBP, hMBP=human MBP, NS signifies P>0.10