Table 6. Effect of CdCl2(C14H21N3O 2) complex on AOM-induced colonic ACF containing four or more aberrant crypts in rats.
No. of crypts per ACF |
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Treatment group | 1 crypt | 2 crypt | 3 crypt | 4 crypt and more | Total ACF | Inhibition % |
Vehicle control group | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 |
Cancer control group | 9 ± 0.43 | 27 ± 3.27 | 21 ± 3.27 | 30 ± 1.27 | 88 ± 6.7 | 0 |
Positive control group | 2 ± 0.03* | 6 ± 0.69* | 5 ± 0.64* | 10 ± 0.26* | 22 ± 2.81* | 75.2* |
Low dosage of complex (25 mg/kg) | 2 ± 0.71* | 5 ± 0.14* | 5 ± 0.19* | 14 ± 1.04* | 26 ± 2.70* | 71.3* |
High dosage of complex (50 mg/kg) | 2 ± 0.41* | 5 ± 0.52* | 4 ± 0.27* | 13 ± 1.13* | 24 ± 1.53* | 73.4* |
Values are expressed as the means ± S.E.M. Significance was set at P < 0.05, compared with cancer control group.