Table 4.
Postoperative transthoracic echocardiographic parameters (measured 3-to-5 days postoperatively) and perioperative laboratory measures in hyperinsulinemic normoglycemic clamp (HNC) and standard therapy groups in patients with aortic stenosis.
| Variable | N | HNC (N = 49) | N | Standard (N = 48) | Difference (HNC minus Standard) (95% CI) | P |
|---|---|---|---|---|---|---|
| Echocardiographic outcomes | ||||||
| LV systolic strain(%)* | 23 | −14.3 ± 3.7 | 29 | −15.2 ± 2.9 | 0.4 (−0.97,1.8) | 0.54 |
| LV systolic strain rate (sec−1)* | 21 | −0.9 ± 0.2 | 28 | −1.0 ± 0.2 | 0 (0.0, 0.1) | 0.27 |
| 3D left ventricular ejection fraction(%)* | 28 | 56 ± 10 | 31 | 58 ± 6 | −1.4 (−5.1, 2.4) | 0.47 |
|
| ||||||
| Laboratory outcomes | Ratio of means (95% CI) | |||||
| NT-pro-BNP (pg/mL)* | 42 | 1465 [950, 2841] | 39 | 1868 [866, 3255] | 0.9 (0.7, 1.2) | 0.50 |
| Troponin T (ng/mL) | 47 | 0.45 [0.26, 0.85] | 47 | 0.42 [0.18, 0.62] | 1.3 (0.9, 1.8) | 0.23 |
| Serum lactate (mmol/L) | 49 | 2.1 [1.6, 2.5] | 48 | 2.4 [1.5, 3.0] | 1.0 (0.8, 1.1) | 0.60 |
| Creatine kinase (U/L) | 45 | 484 [374, 786] | 45 | 481 [368, 897] | 1.0 (0.7, 1.4) | 0.98 |
| Creatine kinase − MB (ng/mL) | 45 | 22 [16, 33] | 45 | 18 [13, 29] | 1.2 (0.9, 1.6) | 0.25 |
Data is presented as mean ±SD or median[IQR]; LV = left ventricle; NT-proBNP =N-terminal of prohormone brain natriuretic peptide.
*
The analysis adjusted for the corresponding baseline measurement