Table 2.
Comparison of Survival of Older Patients Treated with Limited Resection vs. Stereoactic Body Radiotherapy
| Propensity Score Model | No. | Overall Survival HR1 (95% CI)2 | Lung Cancer-specific Survival HR (95% CI) |
|---|---|---|---|
| Primary Analyses | |||
| Adjusted | 2243 | 1.19 (0.97–1.47) | 1.46 (0.97–2.19) |
| Stratified | 2243 | 1.20 (1.00–1.45) | 1.45 (1.01–2.10) |
| Matched | 972 | 1.20 (0.98–1.49) | 1.48 (0.97–2.42) |
| Inverse Probability Weighted | 22403 | 1.00 (0.85–1.18) | 1.36 (0.98–1.89) |
| Secondary Analyses | |||
| Age ≤75 years | 1066 | 1.11 (0.77–1.61) | 1.44 (0.70–2.97) |
| Age >75 years | 1177 | 1.24 (0.95–1.60) | 1.49 (0.91–2.42) |
| Size ≤3 cm | 1902 | 1.21 (0.95–1.53) | 1.38 (0.65–2.96) |
| Size >3 cm | 341 | 1.18 (0.75–1.86) | 1.62 (1.01–2.61) |
| Wedge Resection vs. SBRT | 1699 | 1.22 (0.98–1.52) | 1.45 (0.95–2.21) |
| Segmentectomy vs. SBRT | 906 | 1.55 (1.18–2.03) | 1.80 (1.09–2.97) |
| Limited resection vs. SBRT with lymph node evaluation4 | 2059 | 1.17 (0.91–1.49) | 1.52 (0.93–2.47) |
1
HR: hazard ratio,
2
CI: confidence interval,
3
Observations with extreme weights were deleted,
4
Lymph node evaluation included pre-treatment endobronchial ultrasound guided lymph node biopsy, endoscopic ultrasound guided lymph node biopsy, mediastinoscopy or PET scan in the patients treated with SBRT