Table 3.

List of proteins (based on peptide data in Table 2) that differentiate stricturing CD from CD without stricture with AUC value >0.9. Included are genes associated with the proteins, as well as brief description of protein function based on available literature.

Protein name	Gene name	Reported Functions
Alpha-2-macroglobulin	A2M	Multiple: TNF, IL-1, and IL-8 binding; platelet activation; extracellular matrix organization; negatively regulates complement activation(31)
L-lactate dehydrogenase B chain	LDHB	Catalyzes fermentation of pyruvate to lactate(32)
Calpain small subunit 1	CAPNS1	Thrombosis, extracellular matrix organization and disassembly(33, 34)
Mannose-binding protein C	MBL2	Enhances phagocystosis, activates complement pathway(35)
Apolipoprotein B-100	APOB	Component of chylomicrons, LDL, and VLDL(36)
CD5 antigen-like	CD5L	Inhibits apoptosis, regulates lymphocyte binding(37)
Serum albumin	ALB	Ubiquitous
Filamin-A	FLNA	Promotes actin branching and linking(38)
Uteroglobin	SCGB1A1	Inhibits phospholipase A2, anti-inflammatory effects(39)
Bromodomain testis-specific protein	BRDT	Spermatogenesis(40)
Cathepsin D	CTSD	Endopeptidase activity; mutations linked with several cancers(41)
Proteasome subunit alpha type-7	PSMA7	Part of proteinase complex with broad activity(42)
Ceruloplasmin	CP	Binds copper, involved in iron transport(43)
Oncoprotein-induced transcript 3 protein	OIT3	Unknown; may be involved in hepatocellular function(44)
Prothrombin	F2	Coagulation; converts fibrinogen to fibrin(45)
Putative tenascin-XA	TNXA	Unknown