Table 2.
Association Between Any Maternal Use of Valproate During Pregnancy and Autism Spectrum Disorder and Childhood Autism
| Valproate Exposure | Live Births, No. | Person-Years at Risk | No. With Disorder | Hazard Ratio (95% Cl)
|
Absolute Risk Over 14 y, % (95% CI) | |
|---|---|---|---|---|---|---|
| Crude | Adjusteda | |||||
| Autism Spectrum Disorder | ||||||
| Yes | 508 | 4880 | 14 | 3.0 (1.8-5.1) | 2.9 (1.7-4.9) | 4.42 (2.59-7.46) |
|
| ||||||
| No | 655 107 | 5 793 387 | 5423 | 1 [Reference] | 1 [Reference] | 1.52 (1.47-1.58) |
|
| ||||||
| Childhood Autism | ||||||
| Yes | 508 | 4891 | 9 | 5.4 (2.8-10.4) | 5.2 (2.7-10.0) | 2.50 (1.30-4.81) |
|
| ||||||
| No | 655 107 | 5 803 842 | 2058 | 1 [Reference] | 1 [Reference] | 0.48 (0.45-0.51) |
a
Adjusted for maternal age at conception, paternal age at conception, parental psychiatric history, gestational age, birth weight, sex, congenital malformations, and parity.